反应详情

To a solution of 3-(4-formyl-2,6-dimethyl-phenyl)-acrylic acid (2.2 g, 10.8 mmol) and DIPEA (2.0 mL, 11.9 mmol) in ethanol (80 mL), Pd/C (200 mg, 10% Pd, moistened with 50% water) is added. The suspension is vigorously stirred under 1 bar of H2 for 1 h. The mixture is filtered over Celite and the filtrate is evaporated. The residue is poured onto 1 N aq. HCl/ice and extracted with EA. The organic extract is washed once with 1 N aq. HCl and once with brine, dried over MgSO4, filtered and evaporated to give 3-(4-hydroxymethyl-2,6-dimethyl-phenyl)-propionic acid (2.2 g) as a pale yellow resin; LC-MS: tR=0.71 min.

1. filtrationThe mixture is filtered over Celite
2. customthe filtrate is evaporated
3. additionThe residue is poured onto 1 N aq. HCl/ice
4. extractionextracted with EA
5. extractionThe organic extract
6. washis washed once with 1 N aq. HCl and once with brine
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customevaporated