1,1-Dimethylhydrazine → 2-[4-Cyano(2,2,2-trifluoroethyl)-3-(trifluoromethyl)anilino]-N',N'-dimethylacetohydrazide

HRID 2240867Notes

Reaction equation

HRID 2240867 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:10][C:11](O)=[O:12])=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[CH3:23][N:24]([CH3:26])[NH2:25]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][C:15]([F:16])([F:17])[F:18])[CH2:10][C:11]([NH:25][N:24]([CH3:26])[CH3:23])=[O:12])=[CH:5][C:4]=1[C:19]([F:20])([F:22])[F:21])#[N:2]

Participants

3

Reactant 2

HCID 59761,1-DimethylhydrazineHCID 57633731N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine

Product 1

HCID 113146322-[4-Cyano(2,2,2-trifluoroethyl)-3-(trifluoromethyl)anilino]-N',N'-dimethylacetohydrazide

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine and 1,1-dimethylhydrazine: 1H NMR (400 MHz, CD3OD) δ 7.77 (d, J=9.6 Hz, 1H), 7.14 (bs, 2H), 7.08 (s, 1H), 4.36 (q, J=9.0 Hz, 2H), 4.26 (s, 2H), 2.69 (s, 3H), 2.61 (s, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-548205c24ec341fb94a39f78b0e13380
Source dataset
uspto-grants-2010_05
Patent number
US07723385B2

Reaction notes

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