反应详情

To a solution of 2-amino-N-[2-(2-fluorobenzoyl)-1H-pyrrol-1-yl]acetamide hydrobromide hemihydrate (2.09 g) in 10 ml of anhydrous dimethylformamide and 40 ml of anhydrous DCM were added pyridine (1.89 g) and acetic anhydride (1.22 g). The reaction mixture was stirred at room temperature for 1 hour, subsequently diluted with water and extracted with DCM. The combined organic layers were washed with 5% hydrochloric acid and water, dried over magnesium sulfate and evaporated in vacuo. The residual oil was recrystallized from DCM/ethyl ether affording the product as crystals (1.58 g), m.p. 146°-147° C.

1. extractionextracted with DCM
2. washThe combined organic layers were washed with 5% hydrochloric acid and water
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo
5. customThe residual oil was recrystallized from DCM/ethyl ether affording the product as crystals (1.58 g), m.p. 146°-147° C.