HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 5-Ethynyl-2-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 2-Fluoro-5-((triisopropylsilyl)ethynyl)phenol | HCID 59305361 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Ethynyl-2-fluorophenol | HCID 59305335 | — |
Reaction Steps
2-fluoro-5-((triisopropylsilyl)ethynyl)phenol is dissolved in THF and tetrabutyl ammoniumflouride is added. The solution is stirred overnight at RT. Et2O is added and the solution is washed with H2O, Brine, dried, and the solvent removed. This material is used without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723368B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-aaa542c5d2664447b8f74091e6b99878 |
| Source note | uspto-grants-2010_05 |