HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 67539254, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | HCID 67538669 | HCID 67538669 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67539254 | HCID 67539254 | 74.8% |
Reaction Steps
Into cold mixture of diethyl[(3-bromophenyl)(hydroxy)methyl]phosphonite (30 g) and CH2Cl2 (120 mL) was added diethylaminosulfur trifluoride (16.44 g, 101.53 mmol) and the mixture was stirred for 2 hours. The mixture was then poured into water and washed with NaHCO3 and brine. Purification by ISCO (hexane/EtOAc 1/1) gave diethyl[(3-bromophenyl)(fluoro)methyl]phosphonite (22.6 g); MS m/e (M+H)+ 325.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723368B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-e7156414586e40579ea979f599f42fe3 |
| Source note | uspto-grants-2010_05 |