反应详情

A 25 mL round bottom flask was charged with 4-(2-fluoro-5-((triisopropylsilyl)ethynyl)phenyl)morpholine (0.540 g, 1.50 mmol), diluted with tetrahydrofuran (THF, 1.5 ml) at room temperature. A 1M solution of tetrabutylammonium fluoride in THF (2.0 mL) was added. After 105 minutes reaction the mixture was partitioned between ethylacetate and water, separated, dried with sodium sulfate, and concentrated to an oil by rotary evaporation to yield 0.305 g of 4-(5-ethynyl-2-fluorophenyl)morpholine.

1. customAfter 105 minutes reaction the mixture
2. customwas partitioned between ethylacetate and water
3. customseparated
4. dry with materialdried with sodium sulfate
5. concentrationconcentrated to an oil by rotary evaporation