Ethanol → HCID 25125324, compound

HRID 2241010Notes

Reaction equation

HRID 2241010 reaction equation
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11]([C:13]2[CH:14]=[C:15](C)[CH:16]=[CH:17]C=2)=O)=[CH:6][CH:5]=1.Cl.[CH3:23][NH:24][C:25]([NH2:27])=[NH:26].[C:28]([O-:31])([O-])=O.[Na+].[Na+].[CH3:34]CO>>[NH2:26][C:25]1[N:24]([CH3:23])[C:28](=[O:31])[C:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:1])[F:21])=[CH:9][CH:8]=2)([C:11]2[CH:13]=[CH:14][CH:15]=[C:16]([CH3:17])[CH:34]=2)[N:27]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 67538272HCID 67538272, compoundHCID 178485118HCID 178485118, compound

Product 1

HCID 25125324HCID 25125324, compound

Procedure

This compound was made in a similar manner to Example 89 Step 8 using 1-(4-(difluoromethoxy)phenyl)-2-m-tolylethane-1,2-dione (1.45 g, 5.0 mmol) from the previous step, 1-methylguanidine hydrochloride (821 mg, 7.5 mmol), Na2CO3 (795 mg, 7.5 mmol), and EtOH (10 mL) to provide 1.04 g, 60%, of the title compound as a beige foam.

Workup

  1. customto provide 1.04 g, 60%

Sources & evidence

ORD record
ord-7378f13cb24f47d6acdefdbec2328f6b
Source dataset
uspto-grants-2010_05
Patent number
US07723368B2

Reaction notes

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