Potassium Carbonate → Ethyl 4-({4-[phenyl(3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}oxy)butanoate

HRID 2241050노트

반응식

HRID 2241050 반응식
[C:1]1([C:7](=[C:15]2[CH2:20][C:19]([CH3:22])([CH3:21])[CH2:18][C:17]([CH3:24])([CH3:23])[CH2:16]2)[C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])([O-])=O.[K+].[K+].Cl[CH2:32][CH2:33][CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36]>CC(C)=O>[C:1]1([C:7](=[C:15]2[CH2:16][C:17]([CH3:24])([CH3:23])[CH2:18][C:19]([CH3:22])([CH3:21])[CH2:20]2)[C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:32][CH2:33][CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:12][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18474Ethyl 4-chlorobutyrateHCID 685023444-[Phenyl(3,3,5,5-tetramethylcyclohexylidene)methyl]phenol

생성물 1

HCID 68502642Ethyl 4-({4-[phenyl(3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}oxy)butanoate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

An O-alkylation procedure described for 9 (example 5, step 2) employed using 32 (800 mg, 2.50 mmol), K2CO3 (1.04 g, 7.49 mmol), ethyl 4-chlorobutanoate (715 uL, 5 mmol), and acetone (30 mL). The mixture was refluxed for 15 h and cooled to RT. The mixture was filtered, concentrated, and purified to give ˜1.05 g (purity 80%) of the title product 36. This material was used as such without purification.

후처리

  1. temperatureThe mixture was refluxed for 15 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated
  4. custompurified

출처 및 근거

ORD 기록
ord-e4f2c22b871347c3a167dde447a18dd3
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723393B2

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