反应详情

An O-alkylation procedure described for 9 (example 5, step 2) employed using 32 (800 mg, 2.50 mmol), K2CO3 (1.04 g, 7.49 mmol), ethyl 4-chlorobutanoate (715 uL, 5 mmol), and acetone (30 mL). The mixture was refluxed for 15 h and cooled to RT. The mixture was filtered, concentrated, and purified to give ˜1.05 g (purity 80%) of the title product 36. This material was used as such without purification.

1. temperatureThe mixture was refluxed for 15 h
2. filtrationThe mixture was filtered
3. concentrationconcentrated
4. custompurified