Potassium Carbonate → Ethyl 4-({4-[phenyl(3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}oxy)butanoate

Participants

Reaction Steps

An O-alkylation procedure described for 9 (example 5, step 2) employed using 32 (800 mg, 2.50 mmol), K2CO3 (1.04 g, 7.49 mmol), ethyl 4-chlorobutanoate (715 uL, 5 mmol), and acetone (30 mL). The mixture was refluxed for 15 h and cooled to RT. The mixture was filtered, concentrated, and purified to give ˜1.05 g (purity 80%) of the title product 36. This material was used as such without purification.

Provenance & Evidence