HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2241065Generated: October 31, 2026
Triethylamine → 4-Fluoro-4'-(phenylethynyl)benzophenone
https://huagongshe.com/reaction/2241065
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | (4-Bromophenyl)(4-fluorophenyl)methanone | HCID 74951 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Fluoro-4'-(phenylethynyl)benzophenone | HCID 4095657 | — |
Reaction Steps
In an inert atmosphere glovebox, 4-bromo-4′-fluorobenzophenone (10 g, 35.8 mmol), PdCl2(PPh3)2 (250 mg), CuI (680 mg), phenylacetylene (4.02 g, 1.1 eq), triethylamine (3.6 g, 1 eq), and toluene (25 mL) were combined. The flask was closed and heated to 70° C. for 24 h. The mixture was poured over ice and extracted with methylene chloride, which was separated and evaporated. The residue was recrystallized twice from hot ethanol using decolorizing charcoal to give the title product as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07723458B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-360c8fa57479446d8f1d818abe3570f0 |
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| Source note | uspto-grants-2010_05 |
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