反应详情

温度

70 °C

In an inert atmosphere glovebox, 4-bromo-4′-fluorobenzophenone (10 g, 35.8 mmol), PdCl2(PPh3)2 (250 mg), CuI (680 mg), phenylacetylene (4.02 g, 1.1 eq), triethylamine (3.6 g, 1 eq), and toluene (25 mL) were combined. The flask was closed and heated to 70° C. for 24 h. The mixture was poured over ice and extracted with methylene chloride, which was separated and evaporated. The residue was recrystallized twice from hot ethanol using decolorizing charcoal to give the title product as white crystals.

1. customThe flask was closed
2. additionThe mixture was poured over ice
3. extractionextracted with methylene chloride, which
4. customwas separated
5. customevaporated
6. customThe residue was recrystallized twice from hot ethanol using