反应详情

温度

57.5 °C

The carbamoylation reaction was performed as in Example 1. After about 7-8 hours of stirring the carbamoylation reaction mixture (containing pyridinium bromide, 10-methoxy-5H-dibenz[b,f]azepine, water, toluene, and NaOCN) at room temperature (22° C.), the mixture was heated to 55-60° C., and 500 ml of 10% HCl was added drop-wise and carefully. The reaction mixture was warmed to reflux (89° C.) for 3-4 hours, and then worked up and purified as in Example 1. 32.8 g (58% yield) of crude oxcarbazepine was obtained. The crude afforded 24.9 g (44% overall yield) of pure oxcarbazepine.

1. customThe carbamoylation reaction
2. temperatureThe reaction mixture was warmed
3. temperatureto reflux (89° C.) for 3-4 hours
4. custompurified as in Example 1