反应详情

温度

10 °C

69.6 g (0.5 mol) of 3-piperidinoacrolein, 48.5 g (0.55 mol) of 1,3-dimethylurea and 130.2 g (1.25 mol) of 35% hydrochloric acid were dissolved in 400 ml of methanol and allowed to undergo the reaction at 50° C. for 2 hours. After completion of the reaction, this was cooled to 10° C., and the precipitated crystals were collected by filtration to obtain 90.1 g (yield 85%) of the title compound (purity 99.8%, melting point 174-175° C.).

1. customthe reaction at 50° C. for 2 hours
2. customAfter completion of the reaction
3. filtrationthe precipitated crystals were collected by filtration