Sodium Hydroxide → HCID 59306504, compound

HRID 2241104Notes

Reaction equation

HRID 2241104 reaction equation
[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12](=[O:18])[CH2:13][O:14]C(=O)C)[CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20](=[O:29])/[CH:21]=[CH:22]/[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)#[N:2].[OH-].[Na+]>CO>[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12](=[O:18])[CH2:13][OH:14])[CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20](=[O:29])/[CH:21]=[CH:22]/[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)#[N:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59306469HCID 59306469, compound

Product 1

HCID 59306504HCID 59306504, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 mmol of acetic acid 2-[3-cyano-2-((E)-3-phenyl-allanoylamino)-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-2-oxo-ethyl ester are stirred in 5 ml methanol and 1 ml 45% aqueous NaOH until the reaction is completed. Purification according to the previous preparation affords the desired compound.

Workup

  1. customPurification
  2. customaccording to the previous preparation

Sources & evidence

ORD record
ord-43b386c292e9448694b023e077f3186c
Source dataset
uspto-grants-2010_05
Patent number
US07723523B2

Reaction notes

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