Pentafluorophenol → HCID 86091811, compound

HRID 2241113Notes

Reaction equation

[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[F:12][C:13]1[C:18](O)=[C:17]([F:20])[C:16]([F:21])=[C:15]([F:22])[C:14]=1[F:23]>>[F:12][C:13]1[C:18]([O:8][C:7](=[O:9])[C:6]2[CH:10]=[CH:11][C:3]([CH2:2][Br:1])=[CH:4][CH:5]=2)=[C:17]([F:20])[C:16]([F:21])=[C:15]([F:22])[C:14]=1[F:23]

Participants

Reactant 2

HCID 13041Pentafluorophenol

HCID 225994-(Bromomethyl)benzoic acid

Product 1

HCID 86091811HCID 86091811, compoundYield 56.4%

Procedure

Starting from 4-(bromomethyl)benzoic acid (5.0 g, 23.25 mmol) and pentafluorophenol (4.3 g, 23.25 mmol), applying the same procedure described in Preparation 2, 4-(bromomethyl)benzoic acid pentafluorophenyl ester (5.0 g, 56%) was obtained as an off white solid.

Workup

customdescribed in Preparation 2

Sources & evidence

ORD record: ord-2452644e8d9346f0899428c74c32547e
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07723529B2

Reaction notes

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