反应详情

4-[4-Chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=463.1 (M+H+), was prepared in analogy to example 1, steps A to D. Step A was performed using 4-chloro-3-nitro-benzoyl chloride and yielded 4-(4-chloro-3-nitro-benzoylamino)-benzoic acid ethyl ester. This was reduced to 4-(4-Chloro-3-nitro-benzoylamino)-benzoic acid ethyl ester in step B. This was coupled with 3-chloro-benzenesulfonyl chloride in step C, yielding 4-[4-chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.