Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chlorobenzenesulphonyl chloride → 4-[4-Chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| 반응물 | Ethyl 4-[(4-chloro-3-nitrobenzoyl)amino]benzoate | HCID 711250 | — |
| 생성물 | 4-[4-Chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester | HCID 67549757 | — |
반응 단계
4-[4-Chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid, MS (ISP): m/e=463.1 (M+H+), was prepared in analogy to example 1, steps A to D. Step A was performed using 4-chloro-3-nitro-benzoyl chloride and yielded 4-(4-chloro-3-nitro-benzoylamino)-benzoic acid ethyl ester. This was reduced to 4-(4-Chloro-3-nitro-benzoylamino)-benzoic acid ethyl ester in step B. This was coupled with 3-chloro-benzenesulfonyl chloride in step C, yielding 4-[4-chloro-3-(3-chloro-benzenesulfonylamino)-benzoylamino]-benzoic acid ethyl ester, which was hydrolyzed in step D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07723538B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-ba9ea59c8bdb44959eee2006ec0655c8 |
| 출처 메모 | uspto-grants-2010_05 |