HCID 68509767、化合物 → 5-(3-fluoro-4-hydroxyphenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one

HRID 2241257ノート

反応式

HRID 2241257 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16](=[O:30])[N:17]([CH3:29])[C:18]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[N:19][CH:20]=2)=[CH:11][C:10]=1[F:31])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[F:31][C:10]1[CH:11]=[C:12]([C:15]2[C:16](=[O:30])[N:17]([CH3:29])[C:18]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[N:19][CH:20]=2)[CH:13]=[CH:14][C:9]=1[OH:8]

参加物

3

反応物 1

HCID 68509767HCID 68509767、化合物

生成物 1

HCID 684185945-(3-fluoro-4-hydroxyphenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one収率 82%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 5-(4-(benzyloxy)-3-fluorophenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one (0.139 g, 0.331 mmol) in TFA (1.5 mL) was stirred at 40° C. for 3 hours. The reaction mixture was concentrated to dryness and then purified by flash column chromatography, eluting with 20:1 dichloromethane/MeOH. The desired product (0.089 g, 82%) was obtained as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated to dryness
  2. custompurified by flash column chromatography
  3. washeluting with 20:1 dichloromethane/MeOH

出典と根拠

ORDレコード
ord-b4dc82aad78048449a9203a44cf7bf3d
出典データセット
uspto-grants-2010_05
特許番号
US07723330B2

反応ノート

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