HCID 68518257, compound → HCID 68514986, compound

HRID 2241361Notes

Reaction equation

HRID 2241361 reaction equation
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]4[CH:23]=[C:22]([F:24])[C:21]([N+:25]([O-])=O)=[CH:20][C:19]=4[Cl:28])=[C:11]3[C:10]([CH3:29])=[N:9]2)=[CH:5][CH:4]=1>CCOC(C)=O.C([O-])([O-])=O.[Na+].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]4[C:19]([Cl:28])=[CH:20][C:21]([NH2:25])=[C:22]([F:24])[CH:23]=4)=[C:11]3[C:10]([CH3:29])=[N:9]2)=[CH:30][CH:31]=1

Participants

4

Reactant 1

HCID 68518257HCID 68518257, compound

Product 1

HCID 68514986HCID 68514986, compoundYield 41%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 10340Sodium CarbonateSolvent

Procedure

Prepared by process from Example 92, Step B, substituting 1-(4-methoxybenzyl)-4-(2-chloro-5-fluoro-4-nitrophenoxy)-3-methyl-1H-pyrazolo[3,4-b]pyridine (0.850 g, 1.92 mmol). The reaction mixture was dilute with EtOAc (250 mL) and saturated Na2CO3 (50 mL) was added. The solution was filtered through celite and the filtrate was dried over sodium sulfate and concentrated to provide the product (0.325 g, 35%). The crude material was used in the next step without purification.

Workup

  1. customPrepared by process from Example 92, Step B
  2. additionwas added
  3. filtrationThe solution was filtered through celite
  4. dry with materialthe filtrate was dried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-a3cd13113095494d8da6270ee043db31
Source dataset
uspto-grants-2010_05
Patent number
US07723330B2

Reaction notes

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