Ammonia → 4-Butoxybenzenesulfonamide

HRID 22414Notes

Reaction equation

HRID 22414 reaction equation
[NH3:1].[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=1)[CH2:3][CH2:4][CH3:5]>O>[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13]([NH2:1])(=[O:15])=[O:14])=[CH:9][CH:8]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 5179904-Butoxybenzenesulfonyl Chloride

Product 1

HCID 20491874-Butoxybenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

100 ml of methanolic ammonia solution were added dropwise to 10 g of 4-n-butoxybenzenesulfonyl chloride, while cooling with ice. After the mixture had been stirred at 20° C. for 1/2 hour, water was added, the mixture was acidified to pH 1 to 2 and the product was filtered off with suction, melting point 99° to 101° C.

Workup

  1. temperaturewhile cooling with ice
  2. filtrationthe product was filtered off with suction, melting point 99° to 101° C.

Sources & evidence

ORD record
ord-c44b13c1d4444499a37ed6b544d2882b
Source dataset
uspto-grants-1995_06
Patent number
US05428046

Reaction notes

Loading…