1-Cyclobutylpiperazine → HCID 24756897, compound

HRID 2241533Notes

Reaction equation

HRID 2241533 reaction equation
[N:1]1([C:7]([C:9]2[N:10]([CH2:21][C:22]([F:25])([F:24])[F:23])[C:11]3[C:16]([CH:17]=2)=[CH:15][C:14]([C:18](O)=[O:19])=[CH:13][CH:12]=3)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:26]1([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH2:29][CH2:28][CH2:27]1>>[CH:26]1([N:30]2[CH2:35][CH2:34][N:33]([C:18]([C:14]3[CH:15]=[C:16]4[C:11](=[CH:12][CH:13]=3)[N:10]([CH2:21][C:22]([F:24])([F:23])[F:25])[C:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])=[CH:17]4)=[O:19])[CH2:32][CH2:31]2)[CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 47386021-CyclobutylpiperazineHCID 686815812-(Morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid

Product 1

HCID 24756897HCID 24756897, compoundYield 50%

Procedure

The title compound was synthesized in analogy to example 46, intermediate e), from 2-(morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid and 1-cyclobutylpiperazine (commercially available), to give the desired product as a white solid (50%).

Sources & evidence

ORD record
ord-6ff48cc60a924489b1695a91c73fc283
Source dataset
uspto-grants-2010_05
Patent number
US07723325B2

Reaction notes

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