Morpholine → HCID 68683281, compound

HRID 2241713Notes

Reaction equation

HRID 2241713 reaction equation
[CH3:1][N:2]([CH3:26])[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH:20]([CH3:22])[CH3:21])[C:15]([C:23]([OH:25])=O)=[CH:14]3)=[O:10])[CH2:4]1.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1.Cl.C(N=C=NCCCN(C)C)C>>[CH3:1][N:2]([CH3:26])[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH:20]([CH3:22])[CH3:21])[C:15]([C:23]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:25])=[CH:14]3)=[O:10])[CH2:4]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 68682285HCID 68682285, compound

Product 1

HCID 68683281HCID 68683281, compound

Procedure

The title compound was synthesized in analogy to Example 1, from 5-(3-dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid, morpholine and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as a colorless foam (42%).

Sources & evidence

ORD record
ord-1a8442801874426781feb25a0f9dd326
Source dataset
uspto-grants-2010_05
Patent number
US07723325B2

Reaction notes

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