HCID 24781111, compound → HCID 59203852, compound

HRID 2241818Notes

Reaction equation

HRID 2241818 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]2[N:7]=[C:8]([C:10]3[CH:11]=[N:12][C:13]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[N:14][CH:15]=3)[O:9][C:5]=2[CH:4]=1.[F:26][CH2:27][CH2:28]N(C1C=CC(C2OC3C=C(OC)C=CC=3N=2)=CN=1)C(=O)OC(C)(C)C>>[F:26][CH2:27][CH2:28][N:16]([C:13]1[N:14]=[CH:15][C:10]([C:8]2[O:9][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:25]=[CH:24][C:6]=3[N:7]=2)=[CH:11][N:12]=1)[C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 24781111HCID 24781111, compoundHCID 59203840HCID 59203840, compound

Product 1

HCID 59203852HCID 59203852, compound

Procedure

The title intermediate was synthesized from tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-yl]carbamate according to the procedure described for tert-butyl (2-fluoroethyl)[5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate to give 128 mg. 1H NMR 400 MHz, Chloroform-d) δ ppm 9.33 (s, 2H) 7.66 (d, 1H) 7.14 (d, 1H) 7.00 (dd, 1H) 4.79 (t, 1H) 4.67 (t, 1H) 4.42 (t, 1H) 4.37 (t, 1H) 3.90 (s, 3 H) 1.57 (s, 9H) MS m/z 389 (M+H).

Workup

  1. customto give 128 mg

Sources & evidence

ORD record
ord-a16b444fab7a4373880947635b28942f
Source dataset
uspto-grants-2010_03
Patent number
US07670591B2

Reaction notes

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