反应详情

4-Aminoresorcinol hydrochloride (3.09 mmol) and triethylamine (3.25 mmol) were dissolved in dry methanol (20 mL). 6-Methoxynicotinaldehyde (3.09) was added and the mixture was stirred overnight. The solvents were removed under reduced pressure, the mixture diluted with EtOAc, washed with brine (2×), dried (Na2SO4), filtered and evaporated to give 1.31 g as a dark solid. The crude product was taken to the next step without further purification. MS m/z (M+H) 245.

1. customThe solvents were removed under reduced pressure
2. additionthe mixture diluted with EtOAc
3. washwashed with brine (2×)
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. customevaporated
7. customto give 1.31 g as a dark solid
8. customThe crude product was taken to the next step without further purification