Water → HCID 178522339, compound

HRID 2241849Notes

Reaction equation

HRID 2241849 reaction equation
[NH:1]1[CH:8]=[CH:7][C:5]([NH2:6])=[N:4][C:2]1=[O:3].[C:9]1([CH:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16](Cl)=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O>N1C=CC=CC=1>[C:19]1([CH:15]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:16]([NH:6][C:5]2[CH:7]=[CH:8][NH:1][C:2](=[O:3])[N:4]=2)=[O:17])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 962WaterHCID 746372,2-Diphenylacetyl chlorideHCID 178418229Cytosine

Product 1

HCID 178522339HCID 178522339, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To stirred suspension of (3 gr, 27 mmol) of cytosine (C) in 30 ml of dry pyridine at room temperature (6.85 g, 29.7 mmol) of diphenylacetyl chloride were added in portions. The reaction mixture was stirred at room temperature overnight. TLC indicated the end of the reaction. 2 ml of water was added and the solvent was evaporated under reduced pressure. 100 ml of water were added to the residue and the mixture was stirred vigorously for 30 minutes. The desired product (11) was precipitate and filtered. The white precipitate was washed with 100 ml of ether and dried.

Workup

  1. additionwere added in portions
  2. stirringThe reaction mixture was stirred at room temperature overnight
  3. customthe end of the reaction
  4. customthe solvent was evaporated under reduced pressure
  5. addition100 ml of water were added to the residue
  6. stirringthe mixture was stirred vigorously for 30 minutes
  7. filtrationfiltered
  8. washThe white precipitate was washed with 100 ml of ether
  9. customdried

Sources & evidence

ORD record
ord-a3fb9f4afce14487ab1fbb1ead15c8f6
Source dataset
uspto-grants-2010_03
Patent number
US07671036B2

Reaction notes

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