反应详情

温度

130 °C

2.5 g benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide and 1 g triethylamine hydrochloride are suspended in 60 ml ethylene glycol and stirred at 130° C. for 3 h. The reaction mixture is cooled to ambient temperature and added to 600 ml water. The product is extracted with dichloromethane, the organic layer is dried with sodium sulphate and concentrated under reduced pressure. The residue is recrystallized from N,N-dimethylformamide to give the title compound.

1. temperatureThe reaction mixture is cooled to ambient temperature
2. extractionThe product is extracted with dichloromethane
3. dry with materialthe organic layer is dried with sodium sulphate
4. concentrationconcentrated under reduced pressure
5. customThe residue is recrystallized from N,N-dimethylformamide