Hydrazine hydrate (1:1) → 1-Chloro-4-hydrazinophthalazine

HRID 2241865Notes

Reaction equation

HRID 2241865 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](Cl)=[N:4][N:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:14][NH2:15])=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 784901,4-Dichlorophthalazine

Product 1

HCID 27937521-Chloro-4-hydrazinophthalazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g commercially available dichlorophthalazine are added portionwise at 90° C. to a solution of 50 ml ethanol and 20 ml hydrazine hydrate. After 10 min the reaction mixture is cooled to ambient temperature, the precipitate is filtered with suction and rinsed with ethanol to yield 8.4 g of the title compound.

Workup

  1. filtrationthe precipitate is filtered with suction
  2. washrinsed with ethanol

Sources & evidence

ORD record
ord-0d3702d21f17440595cef4c4f46d64f2
Source dataset
uspto-grants-2010_03
Patent number
US07671050B2

Reaction notes

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