Potassium Carbonate → HCID 59204903, compound

HRID 2241901Notes

Reaction equation

HRID 2241901 reaction equation
Br[CH2:2][C:3](=[O:5])[CH3:4].C(=O)([O-])[O-].[K+].[K+].[F:12][C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CC(C)=O>[F:12][C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1[N:22]1[CH2:27][CH2:26][N:25]([CH2:2][C:3](=[O:5])[CH3:4])[CH2:24][CH2:23]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11715BromoacetoneHCID 27830661-(2-fluoro-4-nitrophenyl)piperazine

Product 1

HCID 59204903HCID 59204903, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Bromoacetone (0.336 ml, 4.00 mmol) and potassium carbonate (1.38 g, 10.00 mmol) were added to a solution of 1-(2-fluoro-4-nitrophenyl)piperazine (compound of Reference Example 52; 0.390 g, 2.00 mmol) in acetone (10 ml) under ice cooling, and the mixture was stirred at room temperature for 18 hours. The residue obtained by evaporation of the solvent under reduced pressure was washed with water to give the title compound (0.467 g, 83%) as a yellow solid.

Workup

  1. customThe residue obtained by evaporation of the solvent under reduced pressure
  2. washwas washed with water

Sources & evidence

ORD record
ord-686ccdc072104c9681e8960ad736ef12
Source dataset
uspto-grants-2010_03
Patent number
US07671058B2

Reaction notes

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