HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium triacetoxyborohydride → 5-Chloro-8-{4-[1-(8-quinolinyl)-4-piperidinyl]-1-piperazinyl}quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 5-Chloro-8-(piperazin-1-yl)quinoline | HCID 58975503 | — |
| Reactant | 1-Quinolin-8-yl-piperidin-4-one | HCID 59204842 | — |
| Product | 5-Chloro-8-{4-[1-(8-quinolinyl)-4-piperidinyl]-1-piperazinyl}quinoline | HCID 12004167 | — |
Reaction Steps
Using the synthetic methods described in previous examples, 5-chloro-8-(piperazin-1-yl)quinoline (Step 3) and 1-quinolin-8-yl-piperidin-4-one (Example A, Step 5, above) were reacted with sodium triacetoxyborohydride to give the desired product as a beige solid; MP. 201-203° C.; MS (ES) m/z (relative intensity) 459 (M+H)+ (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671056B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-1e438a2398584fe89da07f55ae6d5514 |
| Source note | uspto-grants-2010_03 |