HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-8-quinolinol → 5-Fluoro-8-{4-[4-(8-quinolinyl)-1-piperazinyl]-1-piperidinyl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-8-quinolinol | HCID 217907 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-Quinolin-8-yl-piperidin-4-one | HCID 59204842 | — |
| Reactant | 5-Fluoro 8-(piperazin-1-yl)quinoline | HCID 59204873 | — |
| Product | 5-Fluoro-8-{4-[4-(8-quinolinyl)-1-piperazinyl]-1-piperidinyl]quinoline | HCID 12004196 | — |
Reaction Steps
Using the synthetic methods described in previous examples, 5-fluoro 8-(piperazin-1-yl)quinoline (Prepared from commercially available 5-fluoro-8-hydroxyquinoline using the methodology described for Example R, step 3, above) and 1-quinolin-8-yl-piperidin-4-one (Example A, Step 5, above) were reacted with sodium triacetoxyborohydride to give the desired product as a yellow solid; MP. 222-224° C.; MS (ES) m/z (relative intensity) 442 (M+H)+ (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671056B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-dbe8f97cb8ba4c2a93dae14ca5919e1f |
| Source note | uspto-grants-2010_03 |