反应详情

Using the synthetic methods described in previous examples, 5-fluoro 8-(piperazin-1-yl)quinoline (Prepared from commercially available 5-fluoro-8-hydroxyquinoline using the methodology described for Example R, step 3, above) and 1-quinolin-8-yl-piperidin-4-one (Example A, Step 5, above) were reacted with sodium triacetoxyborohydride to give the desired product as a yellow solid; MP. 222-224° C.; MS (ES) m/z (relative intensity) 442 (M+H)+ (100).