(R)-2-phenylpropionyl chloride → 2-(R)-phenyl-propionic acid (Z)-2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl)vinyl ester

HRID 2242062Notes

Reaction equation

HRID 2242062 reaction equation
[C:1]1([C@@H:7]([CH3:11])[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:32])[C:18]=1[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][CH3:31])[CH:23]=1)=[O:21]>>[Cl:32][C:17]1[CH:16]=[N:15][CH:14]=[C:13]([Cl:12])[C:18]=1/[CH:19]=[C:20](\[O:21][C:8](=[O:9])[C@@H:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:11])/[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][CH3:31])[CH:23]=1

Participants

3

Reactant 2

HCID 7161075(R)-2-phenylpropionyl chlorideHCID 66881198HCID 66881198, compound

Product 1

HCID 668999952-(R)-phenyl-propionic acid (Z)-2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl)vinyl esterYield 21%

Procedure

The compound was obtained starting from 2-(R)-phenyl-propionyl chloride and 2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl) -ethanone, following the procedure of Example 7 (0.22 g, 0.48 mmol, 21% yield).

Workup

  1. customThe compound was obtained

Sources & evidence

ORD record
ord-841bd23d759b4a869b2c55c4dedca4ef
Source dataset
uspto-grants-2010_03
Patent number
US07671066B2

Reaction notes

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