反应详情

To a solution of 4-bromo-pyridine-3-carbaldehyde (400 mg, 2.15 mmol) in THF (10 mL) at −78° C. was added dropwise 3.0 M methylmagnesium bromide solution in THF (1.08 mL). After 15 min. the reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate, then purified by flash chromatography eluted with 50% ethyl acetate in hexane to yield 1-(4-bromo-pyridin-3-yl)-ethanol as white crystals.

1. customAfter 15 min. the reaction mixture was quenched with saturated ammonium chloride solution
2. extractionextracted with ethyl acetate
3. custompurified by flash chromatography
4. washeluted with 50% ethyl acetate in hexane