Sodium borohydride → HCID 59205218, compound

HRID 2242140Notes

Reaction equation

HRID 2242140 reaction equation
[C:1]1([CH:7]2[C:15]3[CH:14]=[CH:13][N:12]=[CH:11][C:10]=3[CH:9]([OH:16])[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>C(O)C.C(OCC)(=O)C>[OH:16][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:15]=1[CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[OH:8]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 59205196HCID 59205196, compound

Product 1

HCID 59205218HCID 59205218, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

1-Phenyl-1,3-dihydro-furo[3,4-c]pyridin-3-ol (50 mg) was dissolved in ethanol (2 mL) and treated with sodium borohydride (13 mg). The reaction mixture was stirred for 1 hour and then diluted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate, concentrated, and the residue purified by flash chromatography to yield (3-hydroxymethyl-pyridin-4-yl)-phenyl-methanol as a colorless foam.

Workup

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. customthe residue purified by flash chromatography

Sources & evidence

ORD record
ord-95f84eb94e0c4cf1b4250ac362a6e750
Source dataset
uspto-grants-2010_03
Patent number
US07671065B2

Reaction notes

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