Methanesulfonic Acid → N-(aminomorpholin-4-yl-methylene)-4-methylbenzene-sulfonamide
Reaction equation
CC1C=[C:5]([CH3:7])[N:4]([C:8](=[NH:20])[NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])N=1.CS(O)(=O)=O.N1CC[O:29][CH2:28][CH2:27]1>>[NH2:20][C:8]([N:4]1[CH2:5][CH2:7][O:29][CH2:28][CH2:27]1)=[N:9][S:10]([C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1)(=[O:11])=[O:12]Participants
4
Procedure
The compound of Example 3 was prepared according to the accompanying synthesis procedure from 0.5 ml of N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide solution (0.2 M, acetonitrile) with 19 mg of methanesulfonic acid and 0.5 ml of morpholine solution (1.0 M, acetonitrile) and filed in a substance databank. Calculated mol. wt. 283.35; found mol. wt. (M+H) 284.1
Sources & evidence
- ORD record
- ord-73951b5946a047e7aa768d122cafd499
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07671074B2
Reaction notes
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