Methanesulfonic Acid → N-[amino-(2H-pyrazol-3-yl-amino)-methylene]-4-methylbenzenesulfonamide

HRID 2242161Notes

Reaction equation

HRID 2242161 reaction equation
C[C:2]1[CH:6]=[C:5](C)[N:4]([C:8](=[NH:20])[NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[N:3]=1.CS(O)(=O)=O.[NH2:26]N1C=CC=N1>>[NH2:20][C:8]([NH:4][C:5]1[NH:26][N:3]=[CH:2][CH:6]=1)=[N:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)(=[O:12])=[O:11]

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 118293521H-pyrazol-1-amineHCID 178427489N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide

Product 1

HCID 67175765N-[amino-(2H-pyrazol-3-yl-amino)-methylene]-4-methylbenzenesulfonamide

Procedure

The compound of Example 17 was prepared according to the accompanying synthesis procedure from 0.5 ml of N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide solution (0.2 M, acetonitrile) with 19 mg of methanesulfonic acid and 0.5 ml of 2-aminopyrazole solution (1.0 M, acetonitrile) and filed in a substance databank. Calculated mol. wt. 279.32; found mol. wt. (M+H) 280.3; 559.0 (Dimer)

Sources & evidence

ORD record
ord-6b68de198277427480f4d4284fd091cb
Source dataset
uspto-grants-2010_03
Patent number
US07671074B2

Reaction notes

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