Hydrazine hydrate (1:1) → 4-Isobutylbenzohydrazide

HRID 2242212Notes

Reaction equation

HRID 2242212 reaction equation
O.[NH2:2][NH2:3].[CH2:4]([C:8]1[CH:18]=[CH:17][C:11]([C:12](OCC)=[O:13])=[CH:10][CH:9]=1)[CH:5]([CH3:7])[CH3:6]>O>[CH2:4]([C:8]1[CH:18]=[CH:17][C:11]([C:12]([NH:2][NH2:3])=[O:13])=[CH:10][CH:9]=1)[CH:5]([CH3:7])[CH3:6]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19704460Ethyl 4-isobutylbenzoate

Product 1

HCID 207719354-IsobutylbenzohydrazideYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Hydrazine monohydrate (2.43 g, 48.5 mmol) was added slowly to a heterogeneous solution of ethyl 4-isobutylbenzoate (5.0 g, 24.2 mmol) and H2O and stirred at reflux for 12 hours. The reaction mixture was cooled to room temperature and filtered. The yellow solid was washed with cold water (1×20 mL) and dried to provide the title compound (3.33 g, 78% yield) as a yellow solid.

Workup

  1. temperatureat reflux for 12 hours
  2. filtrationfiltered
  3. washThe yellow solid was washed with cold water (1×20 mL)
  4. customdried

Sources & evidence

ORD record
ord-24d2ab6c494d486e82e639d6eeae7889
Source dataset
uspto-grants-2010_03
Patent number
US07671043B2

Reaction notes

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