反应详情

1,1′-Carbonydiimidazole (2.37 g, 14.6 mmol) was added to a solution of 4-hydroxymethylbenzoic acid (2.00 g, 13.1 mmol) and DMF (50 mL) and stirred at room temperature for 1 hour. N′-Hydroxy-4-isobutylbenzamidine (2.54 g, 13.2 mmol) was added and stirred for 16 hours. The reaction mixture was diluted with water, causing a white solid to precipitate, filtered, washed with water, and dried to give the title compound (3.08 g, 72% yield) as a crude white solid.

1. stirringstirred for 16 hours
2. customto precipitate
3. filtrationfiltered
4. washwashed with water
5. customdried