P-Toluic Acid → {4-[5-(4-Methylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methanol

HRID 2242242Notes

Reaction equation

HRID 2242242 reaction equation
CC1C=CC(C(O)=O)=CC=1.[CH2:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:31]=[CH:30][C:29]([CH2:32][OH:33])=[CH:28][CH:27]=3)[N:22]=2)=[CH:17][CH:16]=1)C(C)C>>[CH3:11][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:31]=[CH:30][C:29]([CH2:32][OH:33])=[CH:28][CH:27]=3)[N:22]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7470P-Toluic AcidHCID 11645224[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methanol

Product 1

HCID 59204295{4-[5-(4-Methylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methanol

Procedure

The title compound was prepared from 4-methylbenzoic acid by procedures analogous to those described in Preparations (8A-8C) for the preparation of {4-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-phenyl}-methanol.

Sources & evidence

ORD record
ord-8a36c4841aa14aaa9e2da1e86b19d01f
Source dataset
uspto-grants-2010_03
Patent number
US07671043B2

Reaction notes

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