反应详情

Hydrogen chloride gas was bubbled for 5 min into a stirred solution of 5-tert-butyl-2-methoxybenzoic acid (5.00 g, 24.0 mmol) in methanol (100 ml) at 0° C., after which time the solution was heated under reflux for 17.5 h. The reaction was cooled, evaporated to dryness under reduced pressure and purified by chromatography on silica using diethyl ether as eluent to afford 5-tert-butyl-2-methoxybenzoic acid methyl ester as a pale cream solid (5.06 g, 95%).

1. temperatureafter which time the solution was heated
2. temperatureunder reflux for 17.5 h
3. temperatureThe reaction was cooled
4. customevaporated to dryness under reduced pressure
5. custompurified by chromatography on silica