(1R,2R)-2-aminocyclopentan-1-ol hydrochloride → HCID 59205402, compound

HRID 2242367Notes

Reaction equation

HRID 2242367 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24]([OH:26])=O)=[CH:6]2)#[N:2].Cl.[NH2:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][C@H:30]1[OH:34]>>[OH:34][C@@H:30]1[CH2:31][CH2:32][CH2:33][C@H:29]1[NH:28][C:24]([C:7]1[N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:21])([F:23])[F:22])[CH:14]=2)[C:9]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2)=[O:26]

Participants

3

Reactant 2

HCID 12886906(1R,2R)-2-aminocyclopentan-1-ol hydrochlorideHCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 59205402HCID 59205402, compound

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and trans-2-aminocyclopentanol hydrochloride in a manner similar to that described in Example 11.

Sources & evidence

ORD record
ord-1c874f66717b4889a0f0b0cb37ee8956
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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