1-Amino-2-butanol → 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (2-hydroxy-butyl)amide

HRID 2242371Notes

Reaction equation

HRID 2242371 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24](O)=[O:25])=[CH:6]2)#[N:2].[NH2:27][CH2:28][CH:29]([OH:32])[CH2:30][CH3:31]>>[OH:32][CH:29]([CH2:30][CH3:31])[CH2:28][NH:27][C:24]([C:7]1[N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:22])([F:21])[F:23])[CH:14]=2)[C:9]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2)=[O:25]

Participants

3

Reactant 2

HCID 261071-Amino-2-butanolHCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 592054335-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (2-hydroxy-butyl)amide

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and 1-amino-2-butanol in a manner similar to that described in Example 11.

Sources & evidence

ORD record
ord-84b0622df3604869806fddfe8bac41d8
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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