(1-Aminocyclopropyl)methanol → HCID 59205411, compound

HRID 2242379Notes

Reaction equation

HRID 2242379 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24](O)=[O:25])=[CH:6]2)#[N:2].[NH2:27][C:28]1([CH2:31][OH:32])[CH2:30][CH2:29]1>>[OH:32][CH2:31][C:28]1([NH:27][C:24]([C:7]2[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:21])[F:22])[CH:14]=3)[C:9]3[C:5]([CH:6]=2)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=3)=[O:25])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 14146220(1-Aminocyclopropyl)methanolHCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 59205411HCID 59205411, compound

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and (1-amino-cyclopropyl)methanol in a manner similar to that described in Example 11.

Sources & evidence

ORD record
ord-c9506e2305c84b24ab3357dfc82bd4a5
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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