HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Aminocyclopropyl)methanol → 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxymethylcyclopropyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Aminocyclopropyl)methanol | HCID 14146220 | — |
| Reactant | 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid | HCID 68543106 | — |
| Product | 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxymethylcyclopropyl)amide | HCID 59205411 | — |
Reaction Steps
The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and (1-amino-cyclopropyl)methanol in a manner similar to that described in Example 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671080B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-c9506e2305c84b24ab3357dfc82bd4a5 |
| Source note | uspto-grants-2010_03 |