HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → HCID 19347508, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-(Trifluoromethyl)-3-hydroxybutyric acid methyl ester | HCID 85646493 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19347508 | HCID 19347508 | 100% |
Reaction Steps
To a solution of the crude 4,4,4-trifluoro-3-hydroxy-3-methylbutyric acid (1.90 g, 10.0 mmol) in methanol (5 ml) was added concentrated aqueous ammonium hydroxide (10 ml), and the reaction stirred for 40 h at room temperature then evaporated to dryness to afford crude 4,4,4,-trifluoro-3-hydroxy-3-methyl butyramide (1.77 g, 100%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671080B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-b403bd1375f8483799fbca623024abf4 |
| Source note | uspto-grants-2010_03 |