Ammonium Hydroxide → HCID 19347508, compound

HRID 2242390Notes

Reaction equation

HRID 2242390 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([C:8]([F:11])([F:10])[F:9])([OH:7])[CH3:6].[OH-].[NH4+:14]>CO>[F:9][C:8]([F:11])([F:10])[C:5]([OH:7])([CH3:6])[CH2:4][C:3]([NH2:14])=[O:2]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 856464933-(Trifluoromethyl)-3-hydroxybutyric acid methyl ester

Product 1

HCID 19347508HCID 19347508, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the crude 4,4,4-trifluoro-3-hydroxy-3-methylbutyric acid (1.90 g, 10.0 mmol) in methanol (5 ml) was added concentrated aqueous ammonium hydroxide (10 ml), and the reaction stirred for 40 h at room temperature then evaporated to dryness to afford crude 4,4,4,-trifluoro-3-hydroxy-3-methyl butyramide (1.77 g, 100%) as a yellow oil.

Workup

  1. customthen evaporated to dryness

Sources & evidence

ORD record
ord-b403bd1375f8483799fbca623024abf4
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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