5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid → HCID 59205408, compound

HRID 2242392Notes

Reaction equation

HRID 2242392 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24](O)=[O:25])=[CH:6]2)#[N:2].[NH2:27][CH2:28][CH2:29][C:30]([CH3:36])([OH:35])[C:31]([F:34])([F:33])[F:32]>>[F:32][C:31]([F:34])([F:33])[C:30]([OH:35])([CH3:36])[CH2:29][CH2:28][NH:27][C:24]([C:7]1[N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:21])[F:22])[CH:14]=2)[C:9]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2)=[O:25]

Participants

3

Reactant 2

HCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acidHCID 790064734-Amino-1,1,1-trifluoro-2-methyl-2-butanol

Product 1

HCID 59205408HCID 59205408, compound

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and 4-amino-1,1,1-trifluoro-2-methylbutan-2-ol in a manner similar to that described in Example 11.

Sources & evidence

ORD record
ord-4c108c051b314fe1b9ebcf30db60d99b
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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