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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2242392Generated: October 27, 2026

5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid → HCID 59205408, compound

https://huagongshe.com/reaction/2242392

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acidHCID 68543106—
Reactant4-Amino-1,1,1-trifluoro-2-methyl-2-butanolHCID 79006473—
ProductHCID 59205408HCID 59205408—

Reaction Steps

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and 4-amino-1,1,1-trifluoro-2-methylbutan-2-ol in a manner similar to that described in Example 11.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07671080B2
Source datasetuspto-grants-2010_03
ORD IDord-4c108c051b314fe1b9ebcf30db60d99b
Source noteuspto-grants-2010_03