反应详情

To compound 63 in EtOH-THF 1:2 was added a large excess of methylamine (30% in water) and left at rt. for 2 weeks. The solution was concentrated to dryness and the residue subjected to a short silica gel column eluted with 2% MeOH in dichloromethane to give a pure (>95%) product M+H+384.5.

1. waitleft at rt
2. waitfor 2 weeks
3. concentrationThe solution was concentrated to dryness
4. washeluted with 2% MeOH in dichloromethane