反应详情

温度

62 °C

A reaction vessel is charged with hydrazine hydrate (1285 g). The solution is heated to approximately 62° C., and 2-chloroadenosine (500 g) is added while maintaining the temperature of approximately 62° C. The mixture is maintained at a target of 62° C. for at least 2 hours, until the level of residual 2-chloroadenosine in the mixture is not more than 0.10%. The mixture is cooled to approximately 40° C. and the mixture is checked to verify the presence of solids. Water (2275 g) is slowly added while maintaining the temperature at approximately 40° C. The mixture is cooled to approximately 10° C. and held for not less than 1 hour. The product is isolated by filtration, washed with water (1195 g) and then with absolute ethanol (1885 g). The product is dried under vacuum at up to 30° C. for not less than 12 hours, to give 2-hydrazinoadenosine.

1. temperaturewhile maintaining the temperature of approximately 62° C
2. temperatureThe mixture is cooled to approximately 40° C.
3. temperaturewhile maintaining the temperature at approximately 40° C
4. temperatureThe mixture is cooled to approximately 10° C.
5. waitheld for not less than 1 hour
6. customThe product is isolated by filtration
7. washwashed with water (1195 g)
8. customThe product is dried under vacuum at up to 30° C. for not less than 12 hours